Mississippi County Arkansas (Vacant / Not In Use) has 6 places on the National Register of Historic Places including 2 places of Statewide significance. Significant places include Burdette School Complex Historic District and Three States Lumber Company Mill Powerhouse, Bank of Osceola, Blytheville, Leachville and Arkansas Southern Railroad Depot--Leachville and Hale Avenue Historic District (Boundary Increase).
Some of the country's most noteable architects helped create the Mississippi County places including Three States Lumber Company, Harrison Construction Company, WPA, Eatmon Construction Company, William Frank Little and Leachville & AR So. RR Blytheville. Prominent architectural styles found in Mississippi Country are Early Commercial, Late 19th And Early 20th Century American Movements and Prairie School.