Mississippi County Arkansas (Historic Districts) has 11 places on the National Register of Historic Places including 1 place of National significance and 1 place of Statewide significance. Significant places include Dyess Colony Center and Burdette School Complex Historic District, Blytheville Commercial Historic District, Hale Avenue Historic District and Hale Avenue Historic District (Boundary Increase).
Some of the country's most noteable architects helped create the Mississippi County places including Howard Eichenbaum, Harrison Construction Company, WPA, William Frank Little, Eatmon Construction Company and G.C. Parlow. Prominent architectural styles found in Mississippi Country are Early Commercial, Art Deco and Greek Revival.