De Soto County Mississippi has 13 places on the National Register of Historic Places including 1 place of National significance and 2 places of Statewide significance. Significant places include Circle G Ranch, Holiday Inn University and Labauve, Felix, House, Dockery House and Hernando Commerce Street Historic District.
Several famous people are associated with these De Soto County historic places including Elvis Aaron Presley and Felix Labauve. Prominent architectural styles found in De Soto Country are Greek Revival, Italianate and Late Victorian.