Pike County Ohio has 8 places on the National Register of Historic Places including 5 places of Statewide significance. Significant places include Eager Inn, Jones-Cutler House, Piketon Historic District, Vanmeter Stone House and Outbuildings and Waverly Canal Historic District.
Prehistoric cultural affiliation(s) include Hopewell dating back to 499 BC.
The famous person Robert Lucas is associated with one of more of the Pike County historic places. Prominent architectural styles found in Pike Country are Federal, Greek Revival and Late Victorian.