Leflore County Mississippi (Historic Districts) has 10 places on the National Register of Historic Places including 1 place of National significance and 2 places of Statewide significance. Significant places include Gritney Neighborhood Historic District, Cotton Row Historic District and Gritney Neighborhood Historic District, Boulevard Subdivision Historic District and Central Commercial and Railroad Historic District.
Some of the country's most noteable architects helped create the Leflore County places including Thomas Henry Jr. Johnson and Frank R. McGeoy. Prominent architectural styles found in Leflore Country are Late 19th And 20th Century Revivals, Queen Anne and Bungalow/Craftsman.